Abcc11 gene

Intermediate frequencies (30–50%) of the dry type are (rs17822931), in the ABCC11 gene is responsible for seen in populations of Southern Asia, the Pacific Islands, Central Asia determination of earwax type. ABCC11. Specificity of human ABCC11 antibody verified on a Protein Array containing target protein plus 383 other non-specific proteins. Graphical displays and utilities But a new study finds most of them still use deodorant. 1. et al. As expected, the ABCC11 WT was detected in the  A single nucleotide polymorphism in the ABCC11 gene, 538G>A (rs17822931), is known to determine human ear wax type. 7, 8, 9 As the mutation (G ABCC11 16:48200821-48281479 . The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. The ABC transporters are large membrane proteins that transport a variety of compounds including lipids, bile salts, toxic compounds and peptides across the cellular membrane. People who have dry earwax as opposed to sticky earwax are highly likely to have the ABCC11 variant and therefore do not produce under arm body odour. The ABCC11 gene is present in the human genome as two alleles, differing in one nucleotide also known as a single nucleotide polymorphism (SNP). Official Pubmed documentation : A SNP in the ABCC11 gene is the determinant of human earwax type. People with BRIC2 have occasional episodes of impaired bile secretion that lead to severe itching (pruritus) and yellowing of the skin and whites of the eyes (jaundice). Gene target information for ABCC11 - ATP binding cassette subfamily C member 11 (human). However, functional properties of One single-nucleotide polymorphism (SNP), 538G>A (Gly180Arg), in the ABCC11 gene determines the type of earwax. In addition, a SNP in this gene is responsible for determination of human earwax type. The two found that 2 percent of participants (117 women) had the ABCC11 gene. The ABCC11 gene determines axillary body odor and the type of earwax. They studied a gene called ABCC11, discovered by them and others in 2001. 17 Jan 2013 Several years ago ago, scientists discovered that a gene called ABCC11 determined whether people produced wet or dry earwax. This The olfactory gene family is the largest known family of genes. 607040 - ATP-BINDING CASSETTE, SUBFAMILY C, MEMBER 11; ABCC11 - MULTIDRUG HGNC Approved Gene Symbol: ABCC11. The AA genotype corresponds to dry earwax, and GA and  20 Mar 2019 rs17822931, also known as c. [provided by RefSeq, Jul 2008]. , Shimizu, H. ABCC11 has a role in the biochemical formation of human axillary odor; The allele frequencies of the ABCC11 locus within ancient populations on the Northern Japanese island of Hokkaido, were investigated. Additionally, it is considered a pleiotropic gene. Lang, T. Anti-perspirant is a type of deodorant that also contains substances that inhibit sweating by clogging sweat glands. 538G>A (G180R) in ABCC11 is not associated with breast cancer risk in Europeans. A SNP in the ABCC11 gene on chromosome 16 at base position 538 of either a guanine or adenine controls for multiple distinct phenotypes. , wet or dry) and is one of most differentiated nonsynonymous SNPs between East. Most human characteristics are controlled by multiple genes (polygenes) although ABCC11 is a peculiar example of a gene with unambiguous phenotypes that is controlled by a SNP. Mutations in this gene cause mitochondrial complex I deficiency. (2001) determined that the ABCC11 gene contains 29 exons. A SNP in the ABCC11 gene is the determinant of human earwax type. The finding came from new research involving 6,495 women who are enrolled in the The team was inspired to see if ethnic groups have different earwax odors after learning that the same gene controls both a person’s underarm because they carry this variant of the ABCC11 gene. A 27-bp deletion in ABCC11 exon 29 was also found in a few individuals of Asian ancestry. People who have 1 or 2 copies of the C variant in the ABCC11 gene have more fat in their earwax, making it wet and sticky. The ABCC11 gene is located on chromosome 16 and encodes the protein named "ATP-binding cassette sub-family C member 11", which influences the reported traits. A SNP in the ABCC11 gene on chromosome 16 at base position 538 of either a guanine or adenine controls for multiple distinct phenotypes . In fact, dry earwax is one method of detecting the presence of the gene in the body, which is most common among East Asians. rs17822931, also known as c. Characteristic of earwax and strength of axillary odor are most likely interconnected. According to a group of researchers from the University of Bristol in the UK, 2 percent of people (at least in their survey) carry a rare version of the gene ABCC11 that prevents their armpits from producing an offensive odor. ABCC11 Antibody (4H6) is a high quality mouse monoclonal recommended for detecting ABCC11 of human origin by WB, IP, IF and ELISA Choose a Store Santa cruz biotechnology ATP-binding cassette transporter sub-family C member 11 is a protein that in humans is encoded by the ABCC11 gene. ABCC11, also known as multidrug resistance-associated protein 8 (MRP8), is a full ABC transporter with a total of 12 putative transmembrane domains and two ATP-binding cassettes . , Takayanagi, S. In their paper published in the journal Nature, the group describes their experiments with mice and what they learned from them. MRP8, and MRP9 (gene symbols ABCC10, ABCC11, and ABCC12), the last three members of the MRP family to be identified, will be discussed. Tammur et al. Here we show that a SNP, 538G → A (rs17822931), in the ABCC11 gene is responsible for determination of earwax type. and Sweden has found that editing a gene involved in producing proteins that promote muscle strength in muscular dystrophy mice models could reduce symptoms. ABCC11 has 2,598 functional associations with biological entities spanning 8 categories (molecular profile, organism, disease, phenotype or trait, functional term, phrase or reference, chemical, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 64 datasets. The idea that the genes around ABCC11 might have something to do with adaptation to cold is suggestive, but almost every East Asian trait of distinction has been hypothesized to have something to Polymorphism in ABCC11 is associated with variation in apocrine gland secretion [MIM i:117800]. It's still possible to be stinky in a different  2 Jan 2013 phisms in the human ABCC11 gene and to explain the impact of ABCC11 538G > A on the apocrine phenotype as well as the anthropological . They found that ABCC11 and ABCC12 were located tandemly, separated by about 200 kb, with the 5-prime ends facing the centromere. These data indicate that expression of the ABCC11 gene  11 Oct 2010 A nonsynonymous single nucleotide polymorphism (SNP), rs17822931-G/A ( 538G>A; Gly180Arg), in the ABCC11 gene determines human  15 Feb 2017 We chose mice as the infectious host because they do not have the Abcc11 gene [11]. The AA genotype corresponds to dry earwax, and GA and GG to wet type. The research, done at the Tokyo Institute of Technology, focused on a variant of the ABCC11 gene, which has already been associated with increased breast cancer risk. Find diseases associated with this biological target and compounds tested against it in bioassay experiments. abcc11 A gene on chromosome 16q12. Reviewed-Annotation score: -Experimental  24 Feb 2014 Smelly earwax is just another of the genetic quirks we inherit as part of one body odor, because they carry this variant of the ABCC11 gene. Not just Koreans, but East Asians in general. I only use deodorant (and I definitely need it). * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. Variations in the gene have been found to be associated with increased breast cancer risk. (2001) determined that the ABCC11 gene contains 31 exons and spans more than 80. The ABCC11 FISH probe is designed to hybridize to the ABCC11 gene and is primarily used for detecting amplifications and deletions associated with the gene. Function: Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides (PubMed:12764137, PubMed:15537867). Since non-functional ABCC11 protein arises from the ABCC11 gene with the 538A contrary to the case with the 538G allele, genetic-based differences in those human phenotypes of earwax are likely due to the presence of functional ABCC11 proteins [3,4]. It was recently reported that the ABCC11 gene has a nonsynonymous SNP 538G>A (rs17822931; Gly180Arg), which is important for determination of the type of human earwax that is expressed. (rs17822931), in the ABCC11 gene is responsible for determination of earwax type. 2011. Restrict the view to a region of the gene by dragging across the histogram to highlight the region of interest, or by using the sliders in the filters panel to the left. Wet/dry types of earwax are determined by the c. It is typically sold under the name anti-perspirant to distinguish it from regular deodorant. According to a LiveScience article from 2013, scientists discovered there was actually a gene called ABCC11, which determines if a person is smelly or not. Bera et al. Armpit odor is caused by acid left behind when bacteria breaks down protein in human sweat. Consequently there are far more people carrying the mutation for red hair than people actually having red hair. This gene contains instructions for a protein that moves fat into, and out of, your cells. The ABCC11 gene encodes the multidrug resistance-associated protein 8 that consists of 1382 amino acids and contains 2 ATP-binding domains and 12 trans-membrane domains. Interestingly  We looked at a place in your DNA (a genetic marker) that affects your chances of ABCC11 gene have more fat in their earwax, making it dark- colored and  Genetic studies have demonstrated that the ABCC11 538G/G and G/A genotypes result in the wet type of earwax, while the 538A/A genotype is associated with  methotrexate and found that this enhanced 5-FU and methotrexate cytotoxicity in PC-6/FU23-26 cells. 29 Jan 2006 (rs17822931), in the ABCC11 gene is responsible for determination of earwax type. at the Institute of Medical Genetics in Cardiff Most human characteristics are controlled by multiple genes (polygenes) although ABCC11 is a peculiar example of a gene with unambiguous phenotypes that is controlled by a SNP. The encoded protein is required for the assembly of the respiratory chain NADH dehydrogenase (complex I), an oligomeric enzymatic complex located in the inner mitochondrial membrane. Ah, the sweet smell of science, an English study published Monday confirms a link between an underarm odor gene and deodorant use. 18 Jan 2013 Two percent of people carry an unusual form of a specific gene (ABCC11) that means their armpits never smell. This gene and family member ABCC12 are determined to be derived by duplication and are both localized to chromosome 16q12. Mutations in the ABCB11 gene can cause benign recurrent intrahepatic cholestasis type 2 (BRIC2). Privacy policy; About SNPedia; Disclaimers The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. The earwax-associated SNP c. Also known as: ENSG00000121270, MRP8. You can thank your ABCC11 gene for your earwax type. The gene is responsible for  6 days ago The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. These data indicate that expression of the ABCC11 gene is induced by 5-FU, and that ABCC11 is directly involved in 5-FU resistance by the efflux transport of the active metabolite FdUMP. The ABCC11 protein helps transport small molecules across apical membranes such as those in apocrine secretory cells. 1 [6–8]. In this study, we provide evidence that the gene ABCC11(MRP8), which encodes an apical efflux pump, is crucial for the formation of the characteristic axillary odor and that a single-nucleotide polymorphism (SNP) 538G-A, which is prominent among Asian people, leads to a nearly complete loss of the At first, we examined the relationship between the ABCC11 gene and MTA cytotoxicity, but correlation was not observed in this study . We then classified 13 lung adenocarcinoma cell lines into three groups based on the genotype of this ABCC11 SNP: G/G, G/A and A/A. ABCC11 FISH PROBE The ABCC11 FISH probe is designed to hybridize to the ABCC11 gene on 16q12. ABCC11 has overall 42% identity and 51% similarity with the MRP5 sequence and the predicted amino acid sequences of gene products show high similarity to those of ABCC5 (Bera et al. (2010) found similar results in a smaller study. Of these proteins, a physiological function has only been established for MRP8, for which a single nucleotide polymorphism determines wet vs dry earwax type. 538G>A single-nucleotide polymorphism in the ABCC11 gene. Single gene sequencing, deletion/duplication analysis and targeted variant analysis is also available for this gene. e. locker room smell. The ABCC11 gene codes for the multi-drug resistance-associated protein 8 (MRP8). 1038/ng1733, PMID 16444273 Multidrug resistance protein (MRP)7, MRP8, and MRP9 (gene symbols ABCC10, ABCC11, and ABCC12) are recently identified members of the MRP family that are at relatively early stages of investigation. The gene ABCC11, encodes an ATP-driven efflux pump for amphipathic anions , , that displays a single nucleotide polymorphism (SNP), 538G→A, leading to a G180R substitution in the corresponding protein. In this context, we examined a relationship between the degree of AO and the ABCC11 genotype. A number sign (#) is used with this entry because of evidence that variation in apocrine gland secretion, which manifests as wet or dry ear wax type, presence or absence of axillary odor, and variation in colostrum secretion, is associated with variation in the ABCC11 gene (607040) on chromosome 16q12. Another gene sequence, ABCC13, does not appear to encode a functional ABC transporter [2, 3]. Red hair is a recessive genetic trait caused by a series of mutations in the melanocortin 1 receptor (MC1R), a gene located on chromosome 16. This probe is FISH confirmed on normal peripheral blood metaphase spreads and interphase nuclei. The variants which are nearly fixed in East Asia around this Multidrug resistance protein (MRP)7, MRP8, and MRP9 (gene symbols ABCC10, ABCC11, and ABCC12) are recently identified members of the MRP family that are at relatively early stages of investigation. Loss of function of the ABC/C11 gene is very common among East Asian populations (80-90% of the population!), but fairly rare in other populations (1 – 3% of Caucasians). The SNPs in and around ABCC11 are a set where East Asians in particular show signs of being different from other world populations. Due to there being two different allelic variants in the ABCC11 gene, humans can have three possible outcomes, either a GG, GA, or AA alleles. This particular variant also plays a role in glandular activity, which explains the osmidrosis and wet-type earwax connection. “That's why Asians  Preti's interest in earwax was piqued by the finding that a small change in a gene known as ABCC11 is related both to underarm odor production and also to  However, nothing is currently known about regulation of this gene. Every primer pair is optimized, experimentally validated, and performance guaranteed. In this study, estradiol (E2) treatment reduced expression of ABCC11 mRNA in estrogen  1 Jun 2009 Specifically, the researchers expressed the ABCC11 gene and variant proteins in cultured human embryonic kidney cells and showed exactly  The type of earwax is determined by a variation in the ABCC11 gene, and is associated with the risks for breast cancer, drug resistance and cold adaptation. [Mol Cancer Ther 2007;6(1):122–7] protein-coding gene in the species Homo sapiens. Additional Information. 1 has been shown  A strong positive selection in mate choice for low-odorant partners with a dysfunctional ABCC11 gene seems a plausible explanation for this striking frequency  25 Oct 2010 Here's what I found, A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene:. People without Gene for Underarm Odor Still Wear Deodorant. MRP7, MRP8, and MRP9 are at early stages of investigation. Use Bio-Rad's PrimePCR assays, controls, templates for your target gene. This page was last edited on 8 June 2007, at 02:30. 324–330, doi:10. 4 kb. ▼ TEXT. A functional assay demonstrated that cells with allele A show a lower excretory activity for cGMP than those with Establishment of this gene variant database (LSDB) was supported by the European Community's Seventh Framework Programme (FP7/2007-2013) under grant agreement No 200754 - the GEN2PHEN project. 538G>A or G180R, is a SNP in the ATP-binding cassette, sub-family C (CFTR/MRP), member 11 ABCC11 gene. 2011: 21-Motoi Nakano: A strong association of axillary osmidrosis with the wet earwax type determined by genotyping of the ABCC11 gene: 2009: 9: 10. (13 co-authors). More information related to gene ABCC11. Correlation of axillary osmidrosis to a SNP in the ABCC11 gene determined by the Smart Amplification Process (SmartAmp) method. Observational study of genotype Functional Associations. Sweat glands produce sweat which, combined with bacteria, result in under You can thank your ABCC11 gene for your earwax type. Those who produce a dry version of earwax apparently also lack the same bacteria that festers in underarms and causes odor. Sinodonty and Sundadonty . The allele frequencies within ethnicities continued to be maintained because the ABCC11 gene is inherited as a haplotype, a group of genes or alleles that tend to be inherited as a single unit. According to a group of researchers from the University of Bristol in the UK, 2 percent of people (at least in their survey) carry a rare version of the gene ABCC11 that prevents their armpits The SNP in the ABCC11 gene will have 16 chromosomes at the base position, with 528 guanines (G) alleles or adenine (A) alleles. The Human Gene Mutation Database. The finding came from new  The gene ABCC11, encodes an ATP-driven efflux pump for ABCC11 gene results in reduced concentrations of apocrine derived axillary odour precursors. A change in a single base in the code for this gene  gene contains the information for a protein that transports fatty substances. The G/G and G/A genotypes  27 Jul 2010 Next, we analyzed the relationship between ABCC11 gene expression and MTA sensitivity of 13 adenocarcinoma cells, but there was no  The gene that determines wet/dry earwax is ABCC11. Having one copy of a dominant gene and one recessive, in a system like you're  20 Feb 2013 Asians typically have an ABCC11 gene variant that produces less oily skin secretions, which are fermented by bacteria. The impact of natural selection on an ABCC11 SNP determining earwax type. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). Multiple splicing variants of two new human ATP-binding cassette transporters, ABCC11 and ABCC12. While most of these genes have a minor to moderate influence on perceiving smells, Gene Heritage has labelled OR5A1 a MAJOR influence on smell sensitivity to beta-ionone based on the findings of various scientific studies. al. 8 Jul 2017 This new project looks at a specific gene, ABCC11, and how it influences the microbes that live on your body, particularly those found in your  7 May 2019 In 2006 Japanese scientists discovered a gene strand (the ABCC11 gene in case you're curious) that determines whether a person has dry or  20 Jul 2015 The ABC/C11 gene determines both the type of earwax a person has and their armpit odor. Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. Two percent of people carry an unusual form of a specific gene (ABCC11) that means their armpits never smell. Though Day and Rodriguez’ study didn’t look at males, Day told LiveScience he thinks their research can be generalized . As a recessive trait it must be inherited from both parents to cause the hair to become red. Band 38, Nummer 3, März 2006, ISSN 1061-4036, S. « hide 10 20 30 40 50 mgfealnwyc kpiaegfwek tpdgafgayt pcaidslvmi vsnsvllglc 60 70 80 90 100 fyriwitlyn akaqiyvlrk myyhcvlwil acccvvepvl rlvmgislfd 110 120 130 140 150 mgdetdlppf evaslmveaf awfamlvlig letkqyvkef rwyvrfgvvy 160 170 180 190 200 vlvadavlld lvlplknsin rtalylciss rccqalfgil llvyipeldl 210 220 230 240 250 ypdyhilnne sldnveydal pggvnicper yasifsgiyf swmtplmqlg 260 270 280 290 300 No sweat? If you have this gene, you may not use deodorant. This protein is responsible for expelling specific types of molecules from within a cell. Recently, a non-synonymous single nucleotide polymorphism (SNP) 538G> A (Gly180Arg) in the human adenosine triphosphate (ATP)-binding cassette (ABC) transporter ABCC11 gene was found to determine the type of earwax. 1186/1471-2156-10-42: Kiyonori Miura: A strong association between human earwax-type and apocrine colostrum secretion from the mammary gland. Status. But the third trouble on that list, it turns out, only afflicts 98% of us. That said, this info pertains to the classic B. Human ABCC11 and ABCC12 gene are located on human chromosome 16q12. I cannot use anti-perspirant, as it gives me a terrible rash. The loss of a functional ABCC11 gene is caused by a 538G>A single-nucleotide polymorphism, resulting in a loss of body odor in people who are specifically homozygous for it. Earwax type is determined by a variation in the ABCC11 gene (1). Multiple alternatively spliced transcript variants have been described for this gene. Cytogenetic location:  ATP-binding cassette sub-family C member 11. ". Download additional test information. People with the gene always have dry earwax. 1 in a tail-to-head orientation with a separation distance of about 20 kb. Amount of body odor depends on ambient temperature and perspiration rate. O. These variations, called SNPs In this study, we provide evidence that the gene ABCC11 (MRP8), which encodes an apical efflux pump, is crucial for the formation of the characteristic axillary odor and that a single-nucleotide polymorphism (SNP) 538G → A, which is prominent among Asian people, leads to a nearly complete loss of the typical odor components in axillary sweat Gene target information for ABCC11. A team of researchers from Canada, the U. , 2001). Upload media Media in category "ABCC11" The following 10 files are in this category, out of 10 total. The T (minor) allele is associated with: Decreased Nipple aspiration fluid (NAF) yields in women. A SNP in the ABCC11 gene on chromosome 16 at base position 538 of either a guanine (G) or adenine (A) gives rise to two allelic variants of the ABC11 gene (G- or A-allele) and as a result, humans can be of three possible genotypes (GG, GA, or AA), and these alleles are responsible for the occurrence of multiple distinct human phenotypes. Thus these two genes were classified into the multidrug resistant-associated protein (MRP) family. The ABCC11 gene is present in the human genome as two alleles, differing in one nucleotide also known as a single nucleotide polymorphism (SNP). Journal of Plastic, Reconstructive and Aesthetic Surgery 63: 1369-1374. These mutations are displayed at the amino acid level across the full length of the gene by default. References The gene variant is known as ABCC11 and the study authors said that the consistency of earwax is a good indication of those who have it. Martin et. ABCC11 is a member of a large gene family called ATP-binding cassette (ABC) transporters. Human earwax This gene is included on the Liver Disease Panel and Jaundice Panel by next-generation sequencing. These three alleles are responsible for the distinct phenotypes that we ABCC11 (ATP Binding Cassette Subfamily C Member 11) is a Protein Coding gene. ABC proteins transport various molecules across extra- and intra-cellular membranes. 1 and is primarily used for detecting amplifications and deletions associated with the gene. 17 x 17 Yabuuchi, H. The SNP 538G>A in the ABCC11 gene was originally identified as a determinant of human earwax type . To try to understand why this SNP might contribute to a benefit in a cold climate, it might help to explore the function of the gene where the SNP occurs. The ABCC11 gene is located on human chromosome 16q12. 1 that encodes a protein of the MRP subfamily of the superfamily of ATP-binding cassette (ABC) transporters, which transport various molecules across extra- and intracellular membranes, many of which are involved in multidrug resistance. Homo sapiens (Human). ABC proteins transport various  Complete information for ABCC11 gene (Protein Coding), ATP Binding Cassette Subfamily C Member 11, including: function, proteins, disorders, pathways,  18 Jan 2013 2 percent of people (at least in their survey) carry a rare version of the gene ABCC11 that prevents their armpits from producing an offensive  9 May 2017 Recently, a single nucleotide polymorphism (SNP) rs17822931 in the ABCC11 gene located on human chromosome 16q12. Interestingly, there is no putative mouse or rat orthologous gene corresponding to human ABCC11 , indicating that ABCC11 is not an orthologous gene but rather a paralogous gene generated by gene duplication within the human genome. The probe can be labeled in one of The product of this gene participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides. , et al. The finding came from new research involving 6,495 women who are enrolled in the Two percent of people carry an unusual form of a specific gene (ABCC11) that means their armpits never smell. Wiki: Sinodonty and Sundadonty are two patterns of features widely found in the dentitions of different populations in East Asia. Several years ago ago, scientists discovered that a gene called ABCC11 determined whether people produced wet or dry earwax. The gene view histogram is a graphical view of mutations across ABCC11. A SNP in the ABCC11 gene is the People with a functioning ABC/C11 gene have wet earwax and body odor, while those with the gene variant causing loss of function have dry earwax and little or no body odor. Of those 117 women, 78 percent of them still wore deodorant even when they didn’t have to. Download Heritable Liver Disease requisition. This determines different ear wax phenotypes, presence or absence of axillary odor, and variation in colostrum secretion. Reverse strand gene: ATP binding cassette subfamily C member 11. Gene. S. Enhances the cellular extrusion of cAMP and cGMP (PubMed:12764137, PubMed:15537867). A; Gly180Arg), in the ABCC11 gene determines human earwax type (i. Changes in the ABCC11 gene result in less fat being moved into earwax, causing a  1 Jan 2018 I think it goes for most East Asians. In: Nature genetics. "The ABCC11 gene is basically the single determinant of whether you do produce underarm odor or not," said Ian Day, a genetic epidemiologist at the University of Bristol who published a paper The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. The G/G and G/A genotypes correspond to the wet type of earwax, whereas A/A correspon This gene encodes a member of the Mrp/NBP35 ATP-binding proteins family. Previous studies have shown that there is a link between a genetic variant located in the ABCC11 gene and under-arm odour. Diseases associated with ABCC11 include Apocrine Gland Secretion, Variation In and Lateral Sinus Thrombosis. Researchers believe that the ABCC11 gene makes our sweaty armpits odorless because it makes us produce less amino acids than normal. Huh. Organism. Anti-ABCC11 antibody produced in rabbit Prestige Antibodies ® Powered by Atlas Antibodies, affinity isolated antibody, buffered aqueous glycerol solution Synonym: Anti-ATP-binding cassette, sub-family C (CFTR/MRP), member 11, Anti-MRP8 (2009) genotyped the polymorphism in the ABCC11 gene in Japanese axillary osmidrosis patients and found the genotypes that cause wet earwax in 78 out of 79, while only 35 percent of the general population had wet earwax genotypes; Inone et al. The ABCC11 gene has been shown to have a functional single‐nucleotide polymorphism (SNP), 538G>A. abcc11 gene

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